The authors concluded  Nerve renew  soccer players have a good initial rate of return to play following ACL reconstruction, which declines over time. Men may be affected more directly than women by the injury itself as opposed to other factors or life events in terms of their potential return to play, they noted. Persistent Postsurgical Pain Aggressive perioperative interventions can reduce the intensity of acute postoperative pain, which reduces the risk of a patient developing persistent postoperative pain. By Lynn Cintron, MD, MS Page  Nerve renew  of  Nerve renew  More than  Nerve renew 5 million surgical procedures are performed in the United States each year..